The sympathetic nervous system and the metabolic syndrome
Identifieur interne : 009284 ( Main/Exploration ); précédent : 009283; suivant : 009285The sympathetic nervous system and the metabolic syndrome
Auteurs : Giuseppe Mancia [Italie] ; Pascal Bousquet [France] ; Jean Luc Elghozi [France] ; Murray Esler [Australie] ; Guido Grassi [Italie] ; Stevo Julius [États-Unis] ; John Reid [Royaume-Uni] ; Peter A. Van Zwieten [Pays-Bas]Source :
- Journal of hypertension [ 0263-6352 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Studies performed in the past two decades have unequivocally shown that several of the components of the metabolic syndrome are associated with indirect and direct markers of adrenergic overdrive. This is the case for hypertension and obesity, in which resting tachycardia, elevated plasma norepinephrine values, increased sympathetic nerve traffic, as well as augmented levels of total and regional norepinephrine spillover have been reported. This is also the case for insulin resistance, i.e. a metabolic condition frequently complicating the various components of the pathological condition identified as the 'metabolic syndrome'. After briefly describing the epidemiological and the cardiovascular risk profile of the disease, this paper will examine the behaviour of the sympathetic nervous system in the metabolic syndrome as well as the mechanisms potentially responsible for this neurogenic abnormality. This will be followed by an analysis of the role played by neuroadrenergic factors in disease progression as well as in the pathogenesis of its complications. Finally, the therapeutic implications of these findings will be highlighted.
Affiliations:
- Australie, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Alsace (région administrative), Grand Est, Hollande-Septentrionale, Michigan, Victoria (État), Écosse, Île-de-France
- Amsterdam, Glasgow, Melbourne, Paris, Strasbourg
- Université d'Amsterdam, Université de Glasgow
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Le document en format XML
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Van Zwieten</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Academic Medical Center University of Amsterdam, Departments of Pharmacotherapy, Cardiology and Cardiopulmonary Surgery</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of hypertension</title><title level="j" type="abbreviated">J. hypertens.</title><idno type="ISSN">0263-6352</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of hypertension</title><title level="j" type="abbreviated">J. hypertens.</title><idno type="ISSN">0263-6352</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term><term>Hypertension</term><term>Insulin</term><term>Nutritional status</term><term>Obesity</term><term>Sleep</term><term>Sympathetic nervous system</term><term>Sympatholytic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Appareil circulatoire pathologie</term><term>Obésité</term><term>Hypertension artérielle</term><term>Système nerveux sympathique</term><term>Sympatholytique</term><term>Insuline</term><term>Sommeil</term><term>Etat nutritionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies performed in the past two decades have unequivocally shown that several of the components of the metabolic syndrome are associated with indirect and direct markers of adrenergic overdrive. This is the case for hypertension and obesity, in which resting tachycardia, elevated plasma norepinephrine values, increased sympathetic nerve traffic, as well as augmented levels of total and regional norepinephrine spillover have been reported. This is also the case for insulin resistance, i.e. a metabolic condition frequently complicating the various components of the pathological condition identified as the 'metabolic syndrome'. After briefly describing the epidemiological and the cardiovascular risk profile of the disease, this paper will examine the behaviour of the sympathetic nervous system in the metabolic syndrome as well as the mechanisms potentially responsible for this neurogenic abnormality. This will be followed by an analysis of the role played by neuroadrenergic factors in disease progression as well as in the pathogenesis of its complications. Finally, the therapeutic implications of these findings will be highlighted.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Hollande-Septentrionale</li><li>Michigan</li><li>Victoria (État)</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Glasgow</li><li>Melbourne</li><li>Paris</li><li>Strasbourg</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université de Glasgow</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name></noRegion><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name></country><country name="France"><region name="Grand Est"><name sortKey="Bousquet, Pascal" sort="Bousquet, Pascal" uniqKey="Bousquet P" first="Pascal" last="Bousquet">Pascal Bousquet</name></region><name sortKey="Luc Elghozi, Jean" sort="Luc Elghozi, Jean" uniqKey="Luc Elghozi J" first="Jean" last="Luc Elghozi">Jean Luc Elghozi</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Esler, Murray" sort="Esler, Murray" uniqKey="Esler M" first="Murray" last="Esler">Murray Esler</name></region></country><country name="États-Unis"><region name="Michigan"><name sortKey="Julius, Stevo" sort="Julius, Stevo" uniqKey="Julius S" first="Stevo" last="Julius">Stevo Julius</name></region></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Reid, John" sort="Reid, John" uniqKey="Reid J" first="John" last="Reid">John Reid</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Zwieten, Peter A" sort="Van Zwieten, Peter A" uniqKey="Van Zwieten P" first="Peter A." last="Van Zwieten">Peter A. Van Zwieten</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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